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SGT-003 CRISPR-Based Gene Editing for DMD

Not Yet RecruitingPhase 1/2Gene Editing

Study Overview

Age
6–13 years
Phase
Phase 1/2
Sponsor
Solid Biosciences
Therapeutic Approach
Gene Editing
Variant Requirement
Any DMD-causing mutation; CRISPR approach targets dystrophin restoration broadly
Eligible Sex
Male
Ambulation
Ambulatory
Countries
United States

Study Requirements and Criteria

Steroid Use

Must be on stable corticosteroid therapy for minimum 3 months

Inclusion Criteria

Ambulatory males aged 6–13 with genetically confirmed DMD. North Star Ambulatory Assessment score ≥18. No prior gene editing therapy.

Exclusion Criteria

Prior gene therapy or CRISPR treatment. Active hepatitis B or C. Immunodeficiency. Significant liver enzyme elevation.

Clinical Trial Registry

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This information is provided for educational purposes only. Always consult the study investigators before making medical decisions.